Probing the Penetration of Antimicrobial Polymyxin Lipopeptides into Gram-Negative Bacteria
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چکیده
منابع مشابه
Probing the Penetration of Antimicrobial Polymyxin Lipopeptides into Gram-Negative Bacteria
The dry antibiotic development pipeline coupled with the emergence of multidrug resistant Gram-negative 'superbugs' has driven the revival of the polymyxin lipopeptide antibiotics. Polymyxin resistance implies a total lack of antibiotics for the treatment of life-threatening infections. The lack of molecular imaging probes that possess native polymyxin-like antibacterial activity is a barrier t...
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Currently, drug resistance, especially against cephalosporins and carbapenems, among gram-negative bacteria is an important challenge, which is further enhanced by the limited availability of drugs against these bugs. There are certain antibiotics (colistin, fosfomycin, temocillin, and rifampicin) that have been revived from the past to tackle the menace of superbugs, including members of Enter...
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ژورنال
عنوان ژورنال: Bioconjugate Chemistry
سال: 2014
ISSN: 1043-1802,1520-4812
DOI: 10.1021/bc500094d